Food like everything around us is made up of chemicals. Around 500 years ago a man named Paracelsus famously said “The dose makes the poison.” Meaning for most chemicals there is a level of exposure below which there are no harmful effects. In foods, these levels are usually known as an acceptable daily intake or more simply put, ADI. An ADI is the amount that you can consume every day for your entire life – safely. Since the first ADI was set some 60 years ago, there have been no cases of adverse effects in the general population associated with exposure below an ADI. ADIs are set by Joint Expert Committee on Food Additives, and also by…us. So how are ADIs set? From experimental studies in animals and humans. We take the lowest dose at where no effects are seen, then apply two safety factors: Ten-fold to account for potential differences between animals and humans, and an additional ten-fold to account for any differences in human sensitivity. Meaning an ADI is usually one hundred times less than the maximum dose at which no effects are seen in animal studies, and because the chemical is tested in animals at different life stages, it’s also protective of humans at different life stages. However, there can be cases of extreme sensitivity in the population, such as people with genetic diseases like phenylketonuria. This is why additional protection such as mandatory labelling is sometimes required. ADIs are highly conservative and ensure we have a safe food supply here in Australia and New Zealand.